Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.32 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL590718 | 0.83 | AGBL2 (0.38) | AGBL2PTGER4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL588556 | 0.83 | AGBL2 (0.38) | AGBL2PTGER4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4019098 | 0.83 | MAPK1 (0.39) | AGBL2MAPK1PTGER4 | |
| SCHEMBL3947856 | 0.74 | APLNR (0.39) | AGBL2MAPK1 | |
| SCHEMBL588356 | 0.69 | L3MBTL1 (0.43) | PTGER4 | |
| SCHEMBL896777 | 0.69 | AKR1C3 (0.44) | AGBL2PTGER4CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL588357 | 0.69 | L3MBTL1 (0.43) | PTGER4 | |
| SCHEMBL3944958 | 0.69 | AGBL2 (0.38) | AGBL2MAPK1PTGER4CYP2D6CYP2C19 | |
| SCHEMBL12985296 | 0.68 | MEN1 (0.44) | AGBL2MAPK1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4070072 | 0.67 | CNR2 (0.45) | MAPK1CNR2GPR88ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |