Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 9/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | EEF2K | O00418 | 3/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030776 | 0.88 | APLNR (0.34) | APLNRNR1I2CNR1CNR2 | |
| SCHEMBL4196483 | 0.85 | CXCR1 (0.35) | APLNRNR1I2 | |
| SCHEMBL3946528 | 0.82 | APLNR (0.34) | APLNRCNR1CNR2 | |
| SCHEMBL4184543 | 0.81 | APLNR (0.38) | APLNRALDH1A1 | |
| SCHEMBL18640955 | 0.80 | CYP1A2 (0.40) | CTSAALDH1A1 | |
| SCHEMBL4021434 | 0.79 | HDAC6 (0.32) | APLNR | |
| SCHEMBL16680694 | 0.77 | APLNR (0.43) | APLNRCTSANR1I2EEF2KKMO | |
| SCHEMBL16680695 | 0.77 | APLNR (0.43) | APLNRCTSANR1I2EEF2KKMO | |
| SCHEMBL12494482 | 0.77 | EEF2K (0.41) | CTSAEEF2KCYP26A1 | |
| SCHEMBL12494479 | 0.77 | EEF2K (0.41) | CTSAEEF2KCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095712-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |