Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023097 | 0.85 | APLNR (0.35) | APLNRNR1I2 | |
| SCHEMBL4030776 | 0.83 | APLNR (0.34) | APLNRNR1I2NTRK1 | |
| SCHEMBL18640937 | 0.82 | SMN1; SMN2 (0.44) | MEN1KMT2ACYP1A2LMNACYP2C19 | |
| SCHEMBL31362647 | 0.82 | SMN1; SMN2 (0.44) | MEN1KMT2ACYP1A2LMNACYP2C19 | |
| SCHEMBL25235485 | 0.80 | KCNB1 (0.34) | CYP1A2MAPTLMNACYP2C9CYP2C19 | |
| SCHEMBL20142638 | 0.79 | ALDH1A1 (0.46) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL18361518 | 0.78 | THRB (0.34) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL18361519 | 0.78 | THRB (0.34) | POLBMEN1KMT2ACYP1A2MAPT | |
| SCHEMBL3946528 | 0.78 | APLNR (0.34) | APLNRNTRK1 | |
| SCHEMBL13437542 | 0.77 | BACE1 (0.33) | POLBAPLNRMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |