Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023097 | 0.88 | APLNR (0.35) | APLNRNR1I2CNR1CNR2 | |
| SCHEMBL4196483 | 0.83 | CXCR1 (0.35) | APLNRNR1I2NTRK1 | |
| SCHEMBL3946528 | 0.81 | APLNR (0.34) | APLNRNTRK1CNR1CNR2 | |
| SCHEMBL4184543 | 0.79 | APLNR (0.38) | APLNRNTRK1 | |
| SCHEMBL4021434 | 0.77 | HDAC6 (0.32) | APLNR | |
| SCHEMBL4019567 | 0.74 | HDAC6 (0.30) | — | |
| SCHEMBL1439307 | 0.74 | HDAC6 (0.30) | — | |
| SCHEMBL1693207 | 0.74 | HDAC6 (0.30) | — | |
| SCHEMBL3015031 | 0.74 | HDAC6 (0.30) | — | |
| SCHEMBL3238364 | 0.74 | HDAC6 (0.41) | APLNRNR1I2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095712-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |