Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 5/20 | 0.49 |
| ▸ | NAMPT | P43490 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026535 | 0.87 | SCARB1 (0.64) | SCARB1NPC1 | |
| SCHEMBL4029830 | 0.79 | SCARB1 (0.46) | SCARB1ALDH1A1KDM4EHPGDCNR2 | |
| SCHEMBL4195183 | 0.73 | SCARB1 (0.52) | SCARB1KDM4EHDAC6CNR2MAPKAPK2 | |
| SCHEMBL4028758 | 0.69 | SCARB1 (0.72) | SCARB1HDAC6CNR2NPC1 | |
| SCHEMBL4030252 | 0.68 | SCARB1 (0.70) | SCARB1ALDH1A1KDM4EHDAC6NPC1 | |
| SCHEMBL4204570 | 0.68 | SCARB1 (0.51) | SCARB1ALDH1A1KDM4EHPGDCNR2 | |
| SCHEMBL4024468 | 0.68 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL4024931 | 0.67 | SCARB1 (0.69) | SCARB1ALDH1A1KDM4EHPGDHDAC6 | |
| SCHEMBL4189175 | 0.67 | SCARB1 (0.69) | SCARB1ALDH1A1KDM4EHDAC6NPC1 | |
| SCHEMBL13746722 | 0.67 | SCARB1 (0.65) | SCARB1HDAC6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |