Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021056 | 0.81 | EP300 (0.51) | CHUKEP300KAT2BKAT8NPC1 | |
| SCHEMBL25899546 | 0.77 | CHUK (0.43) | CHUKKDM4EALDH1A1GLAGAA | |
| SCHEMBL4019913 | 0.75 | CHUK (0.45) | CHUKKDM4EALDH1A1MAPK10MAPT | |
| SCHEMBL9426430 | 0.75 | KDM4E (0.50) | CHUKNPC1HDAC3HDAC1HDAC2 | |
| SCHEMBL14357917 | 0.75 | HDAC1 (0.46) | CHUKHDAC3HDAC1HDAC2KDM4E | |
| Hydrochloric Acid SCHEMBL29373586 | 0.73 | HDAC1 (0.45) | CHUKHDAC3HDAC1HDAC2KDM4E | |
| Hydrochloric Acid SCHEMBL5749683 | 0.73 | HDAC1 (0.45) | CHUKHDAC3HDAC1HDAC2KDM4E | |
| SCHEMBL5657826 | 0.73 | RXFP1 (0.45) | CHUKKDM4EALDH1A1MAPK10MAPT | |
| SCHEMBL5657172 | 0.72 | RXFP1 (0.64) | CHUKNPC1CA1CA2CA9 | |
| SCHEMBL20072220 | 0.71 | ALDH1A1 (0.47) | CHUKKDM4EALDH1A1MAPK10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | claimed |
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | disclosed |