Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | HTR1D | P28221 | 2/20 | 0.56 |
| ▸ | HTR1B | P28222 | 2/20 | 0.56 |
| ▸ | HTR1F | P30939 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | FABP4 | P15090 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27849149 | 0.87 | HTR6 (0.68) | HTR6LMNASMN1; SMN2HTR1AHTR1D | |
| SCHEMBL4022039 | 0.86 | HTR6 (0.60) | HTR6LMNASMN1; SMN2HTR1AHTR1D | |
| SCHEMBL4784564 | 0.83 | MEN1 (0.72) | HTR6LMNASMN1; SMN2HTR1AHTR1D | |
| SCHEMBL5758119 | 0.80 | HTR6 (1.00) | HTR6LMNAHTR1AHTR1DHTR1B | |
| SCHEMBL3621599 | 0.80 | HTR6 (0.68) | HTR6LMNAHTR1AHTR1DHTR1B | |
| SCHEMBL29956029 | 0.79 | HTR6 (0.67) | HTR6LMNAHTR1AHTR1DHTR1B | |
| SCHEMBL15757545 | 0.79 | HTR6 (0.67) | HTR6LMNAHTR1AHTR1DHTR1B | |
| SCHEMBL14722685 | 0.79 | LMNA (0.56) | HTR6LMNASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7970560 | 0.79 | FABP4 (0.60) | HTR6LMNASMN1; SMN2FABP4 | |
| SCHEMBL30285505 | 0.79 | FABP4 (0.60) | HTR6LMNASMN1; SMN2FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (publ) (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003703-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2008-01-10 | — | — | WO | disclosed |