Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 4/20 | 0.33 |
| ▸ | WNT3A | P56704 | 4/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750943 | 0.74 | MEN1 (0.51) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL4030413 | 0.73 | NPC1 (0.32) | CTNNB1MAPTPOLBRAB9AIGFBP3 | |
| SCHEMBL5752322 | 0.71 | L3MBTL1 (0.41) | ALDH1A1LMNARAB9AL3MBTL1IGFBP3 | |
| SCHEMBL4034041 | 0.71 | NPC1 (0.36) | CTNNB1WNT3AALDH1A1MAPTHPGD | |
| SCHEMBL4031880 | 0.71 | CTNNB1 (0.34) | CTNNB1WNT3AALDH1A1MAPTHPGD | |
| SCHEMBL5678286 | 0.70 | KDM4E (0.53) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL5678124 | 0.69 | CYP1A2 (0.44) | ALDH1A1MAPTKDM4ELMNAL3MBTL1 | |
| SCHEMBL5753752 | 0.69 | L3MBTL1 (0.39) | ALDH1A1KDM4ELMNAL3MBTL1IGFBP3 | |
| SCHEMBL11049942 | 0.67 | SMN1; SMN2 (0.49) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL4028482 | 0.67 | CYP17A1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222174-B1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA PHARMACEUTICAL (JP) | 2009-05-27 | — | — | EP | disclosed |
| US-6649643-B1 | Antitumor, anticarcinogenic, and antimetastasis agents; benign prostatic hyperplasia, alopecia, endometriosis, uterine myoma, hirsutism, virilism, precocious puberty, mastopathy, and polycystic overay syndrome treatment | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-11-18 | — | — | US | disclosed |