Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.50 |
| ▸ | SCARB1 | Q8WTV0 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026658 | 0.90 | NPC1 (0.57) | SCARB1KDM4EHSD17B10ALDH1A1NPC1 | |
| SCHEMBL4028396 | 0.87 | SCARB1 (0.66) | SCARB1HSD17B10NPC1PTGDR2HDAC1 | |
| SCHEMBL10732414 | 0.81 | CHRM2 (0.64) | FABP4SCARB1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL6753135 | 0.79 | KDM4E (0.67) | FABP4SCARB1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL27542798 | 0.76 | RAB9A (0.54) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL4029779 | 0.76 | SCARB1 (0.82) | FABP4SCARB1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4024465 | 0.75 | CNR2 (0.56) | FABP4SCARB1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL25439045 | 0.74 | HSD17B10 (0.52) | FABP4SCARB1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL31554288 | 0.74 | FABP4 (0.63) | FABP4HDAC1HDAC6 | |
| SCHEMBL6682174 | 0.73 | FABP4 (0.69) | FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |