Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.58 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.44 |
| ▸ | HTR3B | O95264 | 2/20 | 0.44 |
| ▸ | HTR3A | P46098 | 2/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12147196 | 0.83 | CHRNB2 (0.58) | CHRNB2CHRNA4AOC3ADRB1HTR3E | |
| SCHEMBL22876928 | 0.81 | CHRNB2 (0.57) | CHRNB2CHRNA4AOC3ADRB1HTR3E | |
| SCHEMBL30922297 | 0.80 | CHKA (0.51) | HRH3HTR3AKDM4E | |
| SCHEMBL3650490 | 0.80 | POLB (0.51) | HRH3KDM4E | |
| SCHEMBL25376115 | 0.80 | CHRNB2 (0.54) | CHRNB2CHRNA4AOC3ADRB1HTR3E | |
| SCHEMBL14341117 | 0.80 | CHRNB2 (0.54) | CHRNB2CHRNA4AOC3ADRB1HTR3E | |
| SCHEMBL31058076 | 0.79 | WNT3A (0.45) | CHRNB2CHRNA4AOC3HRH3KDM4E | |
| SCHEMBL31073166 | 0.79 | HRH3 (0.44) | AOC3HRH3 | |
| SCHEMBL22411598 | 0.77 | CHRNB2 (0.64) | CHRNB2CHRNA4ADRB1HTR3EHTR3B | |
| SCHEMBL3853696 | 0.76 | HRH3 (0.53) | AOC3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718307-A4 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2009-04-29 | — | — | EP | disclosed |
| EP-1718307-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM, LLC (BM) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005082089-A2 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2005-09-09 | — | — | WO | disclosed |