Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 5/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL399089 | 0.94 | CYP1A2 (0.53) | HTR1ADRD2CYP1A2TAAR1FAAH | |
| SCHEMBL545356 | 0.90 | CYP1A2 (0.56) | HTR1ADRD2CYP1A2TAAR1FAAH | |
| SCHEMBL401235 | 0.86 | HTR1A (0.48) | HTR1ADRD2CYP1A2FAAHHTR1D | |
| SCHEMBL3188068 | 0.86 | HTR1A (0.55) | HTR1ADRD2CYP1A2TAAR1FAAH | |
| SCHEMBL401535 | 0.85 | HTR1A (0.50) | HTR1ADRD2CYP1A2TAAR1FAAH | |
| SCHEMBL402232 | 0.82 | TAAR1 (0.54) | HTR1ADRD2CYP1A2TAAR1FAAH | |
| SCHEMBL399090 | 0.81 | HTR1A (0.50) | HTR1ADRD2CYP1A2TAAR1CYP2D6 | |
| SCHEMBL3189494 | 0.81 | FAAH (0.56) | HTR1ADRD2CYP1A2TAAR1FAAH | |
| SCHEMBL545635 | 0.81 | HTR1A (0.43) | HTR1ACYP1A2HTR1DHTR1BALDH1A1 | |
| SCHEMBL402066 | 0.81 | FAAH (0.54) | HTR1ADRD2CYP1A2TAAR1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101617-B2 | Disubstituted ureas and uses thereof in treating heart failure | AMGEN, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20090099198-A1 | Compounds, Compositions and Methods | CYTOKINETICS, INC. | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099198-A1 | Compounds, Compositions and Methods | TNNI3, TNNC1, TNNT2 | HTR1A 3992/4885DRD2 4679/4885CYP1A2 4662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.