Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.56 |
| ▸ | PPARG | P37231 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 2/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | BID | P55957 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6302375 | 0.79 | CCR2 (0.76) | CCR2 | |
| SCHEMBL4701221 | 0.78 | NPC1 (0.54) | CCR2KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL4023308 | 0.78 | MTNR1A (0.47) | PPARGKMT2AKDM4EALDH1A1KLKB1 | |
| SCHEMBL29258467 | 0.76 | CCR2 (0.64) | CCR2PPARGKMT2AF10NOD2 | |
| SCHEMBL4023414 | 0.76 | SRD5A2 (0.78) | KMT2AF10KDM4EALDH1A1POLB | |
| SCHEMBL7884326 | 0.76 | KMT2A (0.72) | CCR2KMT2AF10NOD2NOD1 | |
| SCHEMBL3964251 | 0.75 | CCR2 (0.74) | CCR2KMT2ANOD2NOD1ALDH1A1 | |
| SCHEMBL29433700 | 0.75 | CCR2 (0.74) | CCR2KMT2ANOD2NOD1ALDH1A1 | |
| SCHEMBL2826893 | 0.75 | FFAR1 (0.60) | — | |
| SCHEMBL7242268 | 0.74 | F10 (0.58) | CCR2PPARGKMT2AF10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171428-B1 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2009-06-17 | — | — | EP | disclosed |
| EP-1171428-A4 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2004-09-15 | — | — | EP | disclosed |
| US-6765005-B2 | BACTERICIDES; ENZYME INHIBITORS | AFFINIUM PHARMACEUTICALS, INC. (CA) | 2004-07-20 | — | — | US | disclosed |
| US-20030139377-A1 | Fab I inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-07-24 | — | — | US | disclosed |
| US-6503903-B1 | Administering 3-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carboxamide derivative | SMITHKLINE BEECHAM CORPORATION | 2003-01-07 | — | — | US | disclosed |
| EP-1171428-A1 | FAB I INHIBITORS | SmithKline Beecham Corporation (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000063187-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139377-A1 | Fab I inhibitors | SERPINB1, TFPI, TFPI2 | CCR2 3198/4885PPARG 3945/4885KMT2A 4421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.