Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | KLK1 | P06870 | 1/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826893 | 0.87 | FFAR1 (0.60) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL6821030 | 0.85 | HDAC1 (0.62) | NPC1MEN1KMT2ARAB9AHDAC1 | |
| SCHEMBL30049411 | 0.85 | HDAC1 (0.62) | NPC1MEN1KMT2ARAB9AHDAC1 | |
| SCHEMBL27204179 | 0.83 | KDM4E (0.58) | NPC1MEN1KMT2ARAB9AHDAC1 | |
| SCHEMBL4023308 | 0.81 | MTNR1A (0.47) | NPC1MEN1KMT2ARAB9AKLKB1 | |
| SCHEMBL2825527 | 0.80 | FFAR1 (0.53) | HDAC1HDAC2HDAC8HDAC6HDAC9 | |
| SCHEMBL5070843 | 0.80 | RAB9A (0.56) | NPC1MEN1KMT2ARAB9AHDAC6 | |
| SCHEMBL4024812 | 0.78 | CCR2 (0.56) | KMT2AKLKB1KDM4EALDH1A1CCR2 | |
| SCHEMBL20853225 | 0.78 | HDAC1 (0.62) | MEN1KMT2AHDAC1HDAC2HDAC8 | |
| SCHEMBL6086266 | 0.78 | HDAC1 (0.62) | RAB9AHDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951315-A2 | PHOSPHOLIPASE INHIBITORS, INCLUDING MULTI-VALENT PHOSPHOLIPASE INHIBITORS, AND USE THEREOF, INCLUDING AS LUMEN-LOCALIZED PHOSPHOLIPASE INHIBITORS | Ilypsa, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056279-A2 | PHOSPHOLIPASE INHIBITORS, INCLUDING MULTI-VALENT PHOSPHOLIPASE INHIBITORS, AND USE THEREOF, INCLUDING AS LUMEN-LOCALIZED PHOSPHOLIPASE INHIBITORS | ILYPSA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |