Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.43 |
| ▸ | NT5E | P21589 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031738 | 0.86 | DHODH (0.45) | MAP4K4CLK4DHODHNT5EMEN1 | |
| SCHEMBL4026356 | 0.84 | NT5E (0.43) | MAP4K4DHODHNT5EMEN1KMT2A | |
| SCHEMBL4027654 | 0.81 | ACP1 (0.48) | CLK4DHODHNT5EAURKAMEN1 | |
| SCHEMBL4022559 | 0.81 | NT5E (0.49) | MAP4K4DHODHNT5EACP1CDK2 | |
| SCHEMBL4025761 | 0.80 | NT5E (0.44) | MAP4K4DHODHNT5EMEN1KMT2A | |
| SCHEMBL4823424 | 0.79 | MAP4K4 (0.43) | MAP4K4DHODHNT5EMEN1KMT2A | |
| SCHEMBL4025078 | 0.79 | RXFP1 (0.42) | MAP4K4KMT2AACP1 | |
| SCHEMBL4032316 | 0.79 | CYP1A2 (0.46) | CLK4DHODHNT5EACP1KDR | |
| SCHEMBL4026216 | 0.78 | FYN (0.46) | KDM1ANT5EMEN1KMT2AACP1 | |
| SCHEMBL4031533 | 0.78 | LMNA (0.47) | CLK4DHODHMEN1KMT2ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339690-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |