Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.45 |
| ▸ | NT5E | P21589 | 2/20 | 0.45 |
| ▸ | ACP1 | P24666 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4026356 | 0.93 | NT5E (0.43) | DHODHNT5EACP1MAP4K4ADORA2A | |
| SCHEMBL4027654 | 0.89 | ACP1 (0.48) | DHODHNT5EACP1MEN1KMT2A | |
| SCHEMBL4025761 | 0.88 | NT5E (0.44) | DHODHNT5EACP1MAP4K4ADORA2A | |
| SCHEMBL4022559 | 0.87 | NT5E (0.49) | DHODHNT5EACP1MAP4K4ABCG2 | |
| SCHEMBL4025213 | 0.86 | DHFR (0.44) | DHODHNT5EACP1MAP4K4MEN1 | |
| SCHEMBL4823424 | 0.85 | MAP4K4 (0.43) | DHODHNT5EACP1MAP4K4ADORA2A | |
| SCHEMBL4025078 | 0.85 | RXFP1 (0.42) | ACP1MAP4K4ADORA2AKMT2AABCG2 | |
| SCHEMBL4032316 | 0.84 | CYP1A2 (0.46) | DHODHNT5EACP1ADORA2AABCG2 | |
| SCHEMBL4031533 | 0.84 | LMNA (0.47) | DHODHADORA2AMEN1KMT2ACLK4 | |
| SCHEMBL4026216 | 0.84 | FYN (0.46) | NT5EACP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339690-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |