Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031738 | 0.84 | DHODH (0.45) | CLK4KMT2ADHODHADORA2AMEN1 | |
| SCHEMBL4029317 | 0.84 | CLK4 (0.48) | LMNAALDH1A1CLK4HSD17B10CYP1A2 | |
| SCHEMBL4026356 | 0.82 | NT5E (0.43) | ALDH1A1KMT2AALOX15DHODHADORA2A | |
| SCHEMBL4027654 | 0.79 | ACP1 (0.48) | LMNAALDH1A1CLK4CYP1A2CYP3A4 | |
| SCHEMBL4022559 | 0.79 | NT5E (0.49) | DHODHTDP1 | |
| SCHEMBL4025213 | 0.78 | DHFR (0.44) | CLK4KMT2ADHODHMEN1CLK2 | |
| SCHEMBL4025761 | 0.78 | NT5E (0.44) | KMT2ADHODHADORA2AKDM4EMEN1 | |
| SCHEMBL4025078 | 0.77 | RXFP1 (0.42) | KMT2AADORA2AKDM4EGAAHPGD | |
| SCHEMBL4823424 | 0.77 | MAP4K4 (0.43) | LMNAALDH1A1KMT2ADHODHADORA2A | |
| SCHEMBL4032316 | 0.77 | CYP1A2 (0.46) | LMNAALDH1A1CLK4CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339690-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |