Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.43 |
| ▸ | ACP1 | P24666 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 4/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031738 | 0.93 | DHODH (0.45) | NT5EACP1ADORA2ADHODHMAP4K4 | |
| SCHEMBL4027654 | 0.87 | ACP1 (0.48) | NT5EACP1DHODHMAPTHPGD | |
| SCHEMBL4032316 | 0.85 | CYP1A2 (0.46) | NT5EACP1ADORA2ADHODHHPGD | |
| SCHEMBL4022559 | 0.85 | NT5E (0.49) | NT5EACP1DHODHMAP4K4TDP1 | |
| SCHEMBL4025213 | 0.84 | DHFR (0.44) | NT5EACP1DHODHMAP4K4MEN1 | |
| SCHEMBL4025761 | 0.83 | NT5E (0.44) | NT5EACP1ADORA2ADHODHMAP4K4 | |
| SCHEMBL4025078 | 0.82 | RXFP1 (0.42) | ACP1ADORA2AMAP4K4HPGDKMT2A | |
| SCHEMBL4823424 | 0.82 | MAP4K4 (0.43) | NT5EACP1ADORA2ADHODHMAP4K4 | |
| SCHEMBL4031533 | 0.82 | LMNA (0.47) | ADORA2ADHODHMAPTHPGDMEN1 | |
| SCHEMBL4026216 | 0.82 | FYN (0.46) | NT5EACP1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339690-B1 | N-TYPE CALCIUM CHANNEL ANTAGONISTS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | disclosed |