Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.41 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22442929 | 0.85 | ADRB2 (0.40) | SLC7A5ITGA4ITGB7 | |
| SCHEMBL487423 | 0.85 | ITGA4 (0.51) | CTSSCTSKSLC7A5ITGA4ITGB7 | |
| SCHEMBL487422 | 0.85 | ITGA4 (0.51) | CTSSCTSKSLC7A5ITGA4ITGB7 | |
| SCHEMBL30759366 | 0.85 | ITGA4 (0.51) | CTSSCTSKSLC7A5ITGA4ITGB7 | |
| SCHEMBL15697338 | 0.83 | ESR1 (0.47) | ESR1ESR2CTSSCTSKLY96 | |
| SCHEMBL8628683 | 0.83 | ESR1 (0.47) | ESR1ESR2CTSSCTSKLY96 | |
| SCHEMBL7464405 | 0.82 | SLC7A5 (0.57) | ESR1ESR2CTSSCTSKLY96 | |
| SCHEMBL16944167 | 0.82 | ESR1 (0.46) | ESR1ESR2CTSSCTSKLY96 | |
| SCHEMBL630703 | 0.82 | SLC7A5 (0.57) | ESR1ESR2CTSSCTSKLY96 | |
| SCHEMBL594571 | 0.82 | SLC7A5 (0.57) | ESR1ESR2CTSSCTSKLY96 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | ZHU JIE | 2009-08-27 | — | — | US | disclosed |
| US-7541470-B2 | Processes for making pioglitazone and compounds of the processes | SYNTHON IP INC. (US) | 2009-06-02 | — | — | US | disclosed |
| US-20070167629-A1 | Processes for making pioglitazone and compounds of the processes | SYNTHON IP INC. | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090216024-A1 | Processes for making pioglitazone and compounds of the processes | PDK4, PDK2, DPP4 | ESR1 2035/4885ESR2 1285/4885CTSS 1794/4885 |
| US-20070167629-A1 | Processes for making pioglitazone and compounds of the processes | PDK4, PDK2, DPP4 | ESR1 2035/4885ESR2 1285/4885CTSS 1794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.