Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 10/20 | 0.46 |
| ▸ | KRAS | P01116 | 2/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4193417 | 0.86 | SCARB1 (0.46) | SCARB1KRASHTR6HRH1CHRM2 | |
| SCHEMBL7467529 | 0.81 | HTR6 (0.47) | SCARB1HTR6HRH1CHRM2HTR1A | |
| SCHEMBL13747590 | 0.80 | L3MBTL1 (0.50) | SCARB1KRASHTR6HRH1CHRM2 | |
| SCHEMBL4727325 | 0.80 | MAPT (0.59) | KRASHTR6HDAC1HDAC6MAPT | |
| SCHEMBL4201950 | 0.79 | SCARB1 (0.66) | SCARB1 | |
| SCHEMBL4211410 | 0.78 | SCARB1 (0.55) | SCARB1HTR6 | |
| SCHEMBL4200388 | 0.77 | SCARB1 (0.73) | SCARB1 | |
| SCHEMBL4024931 | 0.76 | SCARB1 (0.69) | SCARB1HTR6HDAC1HDAC6KDM4E | |
| SCHEMBL3857256 | 0.76 | CA1 (0.65) | HTR6HTR1AHTR2AHDAC1HDAC6 | |
| SCHEMBL1003815 | 0.75 | HDAC1 (0.52) | SCARB1KRASHDAC1HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |