Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP2E1 | P05181 | 6/20 | 0.51 |
| ▸ | CYP2C8 | P10632 | 6/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 6/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.51 |
| ▸ | METAP2 | P50579 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5915188 | 0.89 | NPC1 (0.47) | CTSBNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL4206038 | 0.88 | DAO (0.50) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5915160 | 0.84 | CYP1A2 (0.54) | CTSBNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL5915168 | 0.83 | NPC1 (0.42) | CTSBNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL4033493 | 0.83 | CTSB (0.52) | CTSBNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL5915149 | 0.82 | NPC1 (0.43) | NPC1RAB9ANFKB1NFKB2KMT2A | |
| SCHEMBL5915190 | 0.82 | ALDH1A1 (0.42) | CTSBNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL4355607 | 0.82 | METAP2 (0.45) | NPC1RAB9AMETAP2CYP3A4ALDH1A1 | |
| SCHEMBL4187641 | 0.80 | ALDH1A1 (0.41) | CTSBNPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL5915137 | 0.79 | LMNA (0.39) | CTSBNPC1RAB9ANFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060247280-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2006-11-02 | — | — | US | claimed |
| EP-1379240-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2009-04-08 | — | — | EP | disclosed |
| US-20060247280-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2006-11-02 | — | — | US | disclosed |
| EP-1379240-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002078696-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247280-A1 | Compounds and methods | METAP2, DNPEP, METAP1 | CTSB 91/4885NPC1 3549/4885RAB9A 1333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.