Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 6/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031565 | 0.88 | CXCR2 (0.39) | FEN1ERCC1ERCC4CDK2MAPK8 | |
| SCHEMBL4026226 | 0.88 | MAOB (0.38) | FEN1ERCC1ERCC4MAPK8MAPK10 | |
| SCHEMBL4031044 | 0.84 | NTRK1 (0.41) | FEN1ERCC1ERCC4HSD17B10 | |
| SCHEMBL4027166 | 0.84 | MEN1 (0.37) | FEN1ERCC1ERCC4MAPK8MAPK10 | |
| SCHEMBL4028016 | 0.83 | FEN1 (0.58) | FEN1ERCC1ERCC4CCNE2CCNE1 | |
| SCHEMBL4029257 | 0.83 | FEN1 (0.44) | FEN1ERCC1ERCC4MAPK1 | |
| SCHEMBL4027681 | 0.83 | ERCC1 (0.41) | FEN1ERCC1ERCC4MAPK10 | |
| SCHEMBL4028369 | 0.82 | MEN1 (0.43) | FEN1ERCC1ERCC4MAPK8MAPK10 | |
| SCHEMBL4031571 | 0.81 | ERCC1 (0.40) | FEN1ERCC1ERCC4 | |
| SCHEMBL4027676 | 0.81 | MAPK8 (0.40) | MAPK8MAPK10ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | claimed |