Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028367 | 0.89 | ERCC1 (0.47) | MEN1PKMCASP3KMT2ASENP8 | |
| SCHEMBL4027676 | 0.88 | MAPK8 (0.40) | MAPK8MAPK10L3MBTL1CYP2C9HPGD | |
| SCHEMBL4026226 | 0.83 | MAOB (0.38) | MAPK8MAPK10HTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL4028019 | 0.82 | FEN1 (0.39) | MAPK8MAPK10ERCC1FEN1ERCC4 | |
| SCHEMBL4031565 | 0.81 | CXCR2 (0.39) | MEN1PKMKMT2AMAPK8MAPK10 | |
| SCHEMBL4028505 | 0.81 | ALDH1A1 (0.38) | MAPK8MAPK10HTTL3MBTL1NPSR1 | |
| SCHEMBL4031788 | 0.80 | MEN1 (0.41) | MEN1PKMCASP3KMT2ASENP8 | |
| SCHEMBL4026812 | 0.79 | ERCC1 (0.33) | MEN1KMT2ACYP2C19CYP2D6HPGD | |
| SCHEMBL4031044 | 0.78 | NTRK1 (0.41) | HTTMAPTALDH1A1ERCC1FEN1 | |
| SCHEMBL4027166 | 0.78 | MEN1 (0.37) | MEN1KMT2AMAPK8MAPK10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470113-B1 | PYRIMIDINONE VIRAL POLYMERASE INHIBITORS | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-01-07 | — | — | EP | claimed |