Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1893192 | 0.88 | TSHR (0.62) | TSHRL3MBTL1ALDH1A1HSD17B10CDC25B | |
| SCHEMBL19953657 | 0.85 | PKM (0.47) | TSHRL3MBTL1ALDH1A1HSD17B10PKM | |
| SCHEMBL1898535 | 0.85 | TSHR (0.67) | TSHRL3MBTL1ALDH1A1HSD17B10PKM | |
| SCHEMBL7422565 | 0.78 | TSHR (0.51) | TSHRL3MBTL1ALDH1A1HSD17B10PKM | |
| SCHEMBL2597713 | 0.78 | TSHR (0.56) | TSHRL3MBTL1ALDH1A1HSD17B10PKM | |
| SCHEMBL2644268 | 0.78 | TSHR (0.56) | TSHRL3MBTL1ALDH1A1HSD17B10PKM | |
| SCHEMBL2597760 | 0.77 | TSHR (0.49) | TSHRALDH1A1HSD17B10TDP1KDM4E | |
| SCHEMBL19960628 | 0.76 | PKM (0.48) | TSHRL3MBTL1ALDH1A1HSD17B10PKM | |
| Acetic Acid SCHEMBL27725670 | 0.74 | TSHR (0.46) | TSHRALDH1A1HSD17B10TDP1KDM4E | |
| SCHEMBL11273360 | 0.74 | PIN1 (0.41) | TSHRL3MBTL1TDP1CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049484-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | AstraZeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008022-A1 | ISOINDOLINE DERIVATIVES FOR THE TREATMENT OF ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2008-01-17 | — | — | WO | disclosed |