Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031817 | 0.83 | MAPT (0.47) | MAPTKDM4EGAARAB9ANPC1 | |
| SCHEMBL15880627 | 0.83 | HTT (0.45) | P2RX7HTTMAPTKDM4ERAB9A | |
| SCHEMBL12466023 | 0.82 | KIT (0.41) | MAPTKDM4E | |
| SCHEMBL4034870 | 0.80 | MAPT (0.52) | HTTMAPTKDM4ERAB9ANPC1 | |
| SCHEMBL4037473 | 0.78 | MAPT (0.51) | MAPTKDM4EGAALPAR1LPAR3 | |
| SCHEMBL4037532 | 0.77 | LPAR1 (0.61) | MAPTKDM4ELPAR1LPAR3CYP2C9 | |
| SCHEMBL4031767 | 0.72 | MAPT (0.47) | P2RX7MAPTKDM4ERAB9ANPC1 | |
| SCHEMBL4035675 | 0.72 | MAPT (0.67) | HTTMAPTKDM4ELPAR1LPAR3 | |
| SCHEMBL29775952 | 0.71 | KMO (0.44) | HTTMAPTPOLBKDM4ERAB9A | |
| SCHEMBL11902725 | 0.71 | KMO (0.44) | HTTMAPTPOLBKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |