Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.50 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4034814 | 0.86 | MAPT (0.53) | MAPTKDM4ELPAR1LPAR3SMN1; SMN2 | |
| SCHEMBL4035675 | 0.84 | MAPT (0.67) | MAPTKDM4ELPAR1LPAR3HDAC3 | |
| SCHEMBL4030049 | 0.84 | MAPT (0.60) | MAPTKDM4ELPAR1LPAR3SMN1; SMN2 | |
| SCHEMBL4034870 | 0.83 | MAPT (0.52) | MAPTKDM4ELPAR1LPAR3CYP1A2 | |
| SCHEMBL4028907 | 0.82 | LPAR1 (0.80) | MAPTKDM4ELPAR1LPAR3HDAC3 | |
| SCHEMBL4339483 | 0.81 | NR4A1 (0.44) | MAPTHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4031711 | 0.81 | MAPT (0.51) | MAPTKDM4ELPAR1LPAR3HDAC1 | |
| SCHEMBL4029111 | 0.80 | LPAR1 (0.47) | MAPTKDM4ELPAR1LPAR3BRD4 | |
| SCHEMBL4030555 | 0.80 | MAPT (0.47) | MAPTKDM4ELPAR1LPAR3HDAC1 | |
| SCHEMBL4030546 | 0.80 | MAPT (0.47) | MAPTKDM4ELPAR1LPAR3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |