Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | BLVRB | P30043 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4028262 | 0.83 | DPP4 (0.43) | MAPTKDM4ELPAR1LPAR3SMN1; SMN2 | |
| SCHEMBL4031767 | 0.83 | MAPT (0.47) | MAPTKDM4ELPAR1LPAR3SMN1; SMN2 | |
| SCHEMBL4030971 | 0.82 | LPAR1 (0.74) | MAPTKDM4ELPAR1LPAR3SMN1; SMN2 | |
| SCHEMBL4035675 | 0.80 | MAPT (0.67) | MAPTKDM4ELPAR1LPAR3SMN1; SMN2 | |
| SCHEMBL4034724 | 0.77 | EPAS1 (0.51) | MAPTALDH1A1KMT2AEPAS1GAA | |
| SCHEMBL15880627 | 0.77 | HTT (0.45) | MAPTKDM4ELPAR1LPAR3SMN1; SMN2 | |
| SCHEMBL4034870 | 0.77 | MAPT (0.52) | MAPTKDM4ELPAR1LPAR3SMN1; SMN2 | |
| SCHEMBL4032083 | 0.77 | LPAR1 (0.64) | MAPTKDM4ELPAR1LPAR3 | |
| SCHEMBL12466023 | 0.76 | KIT (0.41) | MAPTKDM4EALDH1A1 | |
| SCHEMBL4037473 | 0.75 | MAPT (0.51) | MAPTKDM4ELPAR1LPAR3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |