Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.47 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 10/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4033785 | 0.85 | MAPT (0.50) | LPAR1LPAR3MAPTKDM4EFLT1 | |
| SCHEMBL4037473 | 0.80 | MAPT (0.51) | LPAR1LPAR3MAPTKDM4EBRD4 | |
| SCHEMBL4031102 | 0.80 | LPAR1 (0.61) | LPAR1LPAR3MAPTKDM4E | |
| SCHEMBL4034814 | 0.80 | MAPT (0.53) | LPAR1LPAR3MAPTKDM4EBRD4 | |
| SCHEMBL4035675 | 0.78 | MAPT (0.67) | LPAR1LPAR3MAPTKDM4EBRD4 | |
| SCHEMBL4030049 | 0.78 | MAPT (0.60) | LPAR1LPAR3MAPTKDM4ETP53 | |
| SCHEMBL4032711 | 0.75 | LPAR1 (0.48) | LPAR1LPAR3MAPTKDM4EBRD4 | |
| SCHEMBL4031711 | 0.75 | MAPT (0.51) | LPAR1LPAR3MAPTKDM4EBRD4 | |
| SCHEMBL4030546 | 0.74 | MAPT (0.47) | LPAR1LPAR3MAPTKDM4ETP53 | |
| SCHEMBL4030555 | 0.74 | MAPT (0.47) | LPAR1LPAR3MAPTKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |