Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030555 | 1.00 | MAPT (0.47) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL4030354 | 0.85 | MAPT (0.48) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL4033303 | 0.84 | LPAR1 (0.74) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL4034814 | 0.82 | MAPT (0.53) | MAPTKDM4ERAB9ANPC1LPAR1 | |
| SCHEMBL4035675 | 0.80 | MAPT (0.67) | MAPTMEN1KMT2AKDM4ELPAR1 | |
| SCHEMBL4030049 | 0.80 | MAPT (0.60) | MAPTMEN1KMT2AKDM4ERAB9A | |
| SCHEMBL4037473 | 0.80 | MAPT (0.51) | MAPTKDM4ELPAR1LPAR3ALDH1A1 | |
| SCHEMBL11520909 | 0.79 | ALDH1A1 (0.47) | MAPTMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4033687 | 0.79 | LPAR1 (0.62) | MAPTMEN1KMT2AKDM4ELPAR1 | |
| SCHEMBL4031711 | 0.77 | MAPT (0.51) | MAPTKDM4ELPAR1LPAR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |