SCHEMBL4029305

SCHEMBL4029305

CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=O)N1CC#N

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 4/20 0.78
PGR P06401 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29921612 1.00 AR (0.78) ARPGR
SCHEMBL4027208 0.90 AR (0.74) ARPGR
SCHEMBL23260981 0.89 AR (0.72) AR
SCHEMBL1387845 0.89 AR (0.62) ARPGR
SCHEMBL1389052 0.89 AR (0.72) ARPGR
SCHEMBL8174307 0.88 AR (0.72) ARPGR
SCHEMBL7759712 0.88 AR (0.66) ARPGR
SCHEMBL633857 0.88 AR (0.71) ARPGR
SCHEMBL8704575 0.88 AR (0.77) ARPGR
SCHEMBL7783753 0.88 AR (0.77) ARPGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3357513-B1 PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF KANGPU BIOPHARMACEUTICALS LTD (CN) 2023-10-25 EP disclosed
EP-3527210-B1 COMBINED COMPOSITION COMPRISING A BENZOHETEROCYCLIC COMPOUND AND AN ANDROGEN RECEPTOR PATHWAY MODULATOR AND USES THEREOF KANGPU BIOPHARMACEUTICALS LTD (CN) 2021-06-09 EP disclosed
US-10933059-B2 Combination, application thereof and treatment method KANGPU BIOPHARMACEUTICALS. LTD. (CN) 2021-03-02 US disclosed
US-20190328722-A1 COMBINATION, APPLICATION THEREOF AND TREATMENT METHOD KANGPU BIOPHARMACEUTICALS, LTD. (CN) 2019-10-31 US disclosed
EP-3527210-A1 COMPOSITION, APPLICATION THEREOF AND TREATMENT METHOD Kangpu Biopharmaceuticals, Ltd. (CN) 2019-08-21 EP disclosed
EP-3357513-A1 PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF Kangpu Biopharmaceuticals, Ltd. (CN) 2018-08-08 EP disclosed
US-9205102-B2 Method for treatment of castration-resistant prostate cancer THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-12-08 US disclosed
US-9205102-B2 Method for treatment of castration-resistant prostate cancer THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-12-08 US disclosed
US-20150157656-A1 Method for Treatment of Castration-Resistant Prostate Cancer THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-06-11 US disclosed
US-20150157656-A1 Method for Treatment of Castration-Resistant Prostate Cancer THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-06-11 US disclosed
EP-0671156-B1 Process to prepare cosmetic or pharmaceutical compositions containing liposomes AVENTIS PHARMA SA (FR) 2001-10-24 EP disclosed
US-6162444-A Cosmetic or pharmaceutical compositions HOECHST MARION ROUSSEL (FR) 2000-12-19 US disclosed
CN-1049214-C Phenylimidazolidines, process for their preparation, their use as medicaments and pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 2000-02-09 CN disclosed
US-RE35956-E Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1998-11-10 US disclosed
US-5627201-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1997-05-06 US disclosed
EP-0494819-B1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1996-07-10 EP disclosed
EP-0671156-A1 Cosmetic or pharmaceutical compositions containing liposomes ROUSSEL UCLAF (FR) 1995-09-13 EP disclosed
US-5411981-A Phenylimidazolidines having antiandrogenic activity ROUSSEL UCLAF (FR) 1995-05-02 US disclosed
CN-1063102-A New phenylimidazolidines,, prepare they method, they are as the application of medicine and the pharmaceutical composition that contains them ROUSSEL UCLAF (FR) 1992-07-29 CN disclosed
EP-0494819-A1 Phenylimidazolidines, their process for fabrication, their application as medicaments and the pharmaceutical compositions containing them ROUSSEL UCLAF (FR) 1992-07-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190328722-A1 COMBINATION, APPLICATION THEREOF AND TREATMENT METHOD CYP21A2, CYP17A1, NR5A1 AR 5/4885PGR 96/4885
US-10933059-B2 Combination, application thereof and treatment method CYP21A2, CYP17A1, NR5A1 AR 5/4885PGR 96/4885
US-20150157656-A1 Method for Treatment of Castration-Resistant Prostate Cancer IGFBP5, IGFBP2, IGFBP1 AR 7/4885PGR 414/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.