Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.45 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032643 | 0.83 | TSHR (0.51) | GPBAR1NTRK1MAPTKMT2ATSHR | |
| SCHEMBL13733019 | 0.82 | GPBAR1 (0.64) | GPBAR1EPAS1MAPTPOLBMEN1 | |
| SCHEMBL4029460 | 0.81 | NPSR1 (0.61) | NTRK1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL4034243 | 0.81 | KMT2A (0.49) | NTRK1MAPTMEN1KMT2ATSHR | |
| SCHEMBL11420447 | 0.79 | GPBAR1 (0.61) | GPBAR1EPAS1MAPTPOLBMEN1 | |
| SCHEMBL27936782 | 0.79 | GPBAR1 (0.53) | GPBAR1EPAS1MAPTPOLBBRD4 | |
| SCHEMBL13734246 | 0.79 | GPBAR1 (0.61) | GPBAR1EPAS1MAPTPOLBMEN1 | |
| SCHEMBL4033713 | 0.78 | LPAR1 (0.48) | GPBAR1NTRK1EPAS1KMT2A | |
| SCHEMBL5777101 | 0.77 | RXRA (0.54) | GPBAR1MAPTBRD4IP6K1IP6K3 | |
| SCHEMBL27936779 | 0.77 | GPBAR1 (0.55) | GPBAR1EPAS1MAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |