Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029460 | 0.84 | NPSR1 (0.61) | KMT2ATSHRHTTNPSR1ALDH1A1 | |
| SCHEMBL4032643 | 0.84 | TSHR (0.51) | KMT2ATSHRHTTNPSR1ALDH1A1 | |
| SCHEMBL9903838 | 0.83 | NPSR1 (0.48) | KMT2ACACNA1FABCB1CACNA1DCACNA1S | |
| SCHEMBL4029417 | 0.81 | GPBAR1 (0.53) | KMT2ATSHRHTTNPSR1ALDH1A1 | |
| SCHEMBL2473629 | 0.78 | KMT2A (0.51) | KMT2ACACNA1FABCB1CACNA1DCACNA1S | |
| SCHEMBL4033731 | 0.78 | LPAR1 (0.51) | KMT2ANPSR1MAPTGAA | |
| SCHEMBL4037282 | 0.77 | MAPT (0.52) | KMT2ATSHRHTTNPSR1ALDH1A1 | |
| SCHEMBL2470464 | 0.75 | CACNA1F (0.50) | KMT2ACACNA1FABCB1CACNA1DCACNA1S | |
| SCHEMBL4028725 | 0.74 | MAPT (0.49) | KMT2ATSHRHTTNPSR1ALDH1A1 | |
| SCHEMBL5527223 | 0.74 | MEN1 (0.61) | KMT2ATSHRHTTNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |