Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029460 | 0.84 | NPSR1 (0.61) | TSHRGAAMAPTHTTNTRK1 | |
| SCHEMBL4034243 | 0.84 | KMT2A (0.49) | TSHRGAAMAPTHTTNTRK1 | |
| SCHEMBL4029417 | 0.83 | GPBAR1 (0.53) | TSHRGPBAR1MAPTHTTNTRK1 | |
| SCHEMBL4028725 | 0.83 | MAPT (0.49) | TSHRGAAGPBAR1GABRA5MAPT | |
| SCHEMBL4594713 | 0.81 | GPBAR1 (0.62) | TSHRGAAGPBAR1GABRA5HTT | |
| SCHEMBL8350434 | 0.80 | ALDH1A1 (0.50) | TSHRGPBAR1NPSR1ALDH1A1 | |
| SCHEMBL27918170 | 0.79 | GPBAR1 (0.63) | TSHRGAAGPBAR1GABRA5MAPT | |
| SCHEMBL4037473 | 0.78 | MAPT (0.51) | TSHRGAAMAPTKDM4EALDH1A1 | |
| SCHEMBL2471876 | 0.78 | GPBAR1 (0.62) | TSHRGAAGPBAR1GABRA5HTT | |
| SCHEMBL4031784 | 0.78 | LPAR1 (0.51) | GPBAR1GABRA5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |