Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.38 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.38 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037667 | 0.86 | LPAR1 (0.48) | MAPTKDM4ELPAR1LPAR3LPAR2 | |
| SCHEMBL4035059 | 0.84 | ALDH1A1 (0.51) | MAPTKDM4ELPAR1LPAR3LPAR2 | |
| SCHEMBL4038441 | 0.81 | HDAC1 (0.50) | MAPTKDM4ELPAR1LPAR3LPAR2 | |
| SCHEMBL4031792 | 0.81 | KDM4E (0.45) | MAPTKDM4ELPAR1LPAR3LPAR2 | |
| SCHEMBL3706068 | 0.80 | MAPT (0.52) | MAPTKDM4ELPAR1LPAR3LPAR2 | |
| SCHEMBL4029548 | 0.80 | ATM (0.57) | MAPTKDM4ELPAR1LPAR3LPAR2 | |
| SCHEMBL4032063 | 0.79 | LPAR1 (0.47) | MAPTKDM4ELPAR1LPAR3LPAR2 | |
| SCHEMBL4031208 | 0.78 | LPAR1 (0.73) | MAPTKDM4ELPAR1LPAR3LPAR2 | |
| SCHEMBL4034870 | 0.78 | MAPT (0.52) | MAPTKDM4ELPAR1LPAR3LPAR2 | |
| SCHEMBL12467498 | 0.78 | MAPT (0.52) | MAPTKDM4ELPAR1LPAR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |