Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035059 | 0.88 | ALDH1A1 (0.51) | HDAC1LPAR1KDM4EMAPTALDH1A1 | |
| SCHEMBL4031792 | 0.82 | KDM4E (0.45) | LPAR1KDM4EMAPTHTR5AALDH1A1 | |
| SCHEMBL4030885 | 0.82 | LPAR1 (0.66) | HDAC1LPAR1KDM4EMAPTTP53 | |
| SCHEMBL4029454 | 0.81 | MAPT (0.46) | HDAC1LPAR1KDM4EMAPTMEN1 | |
| SCHEMBL4037667 | 0.79 | LPAR1 (0.48) | HDAC1LPAR1KDM4EMAPTTP53 | |
| SCHEMBL4032063 | 0.76 | LPAR1 (0.47) | LPAR1KDM4EMAPTALDH1A1MEN1 | |
| SCHEMBL4031158 | 0.75 | MEN1 (0.43) | HDAC1LPAR1HTR5AHTR1ADRD2 | |
| SCHEMBL4029548 | 0.75 | ATM (0.57) | LPAR1KDM4EMAPTTP53TSHR | |
| SCHEMBL3706068 | 0.73 | MAPT (0.52) | HDAC1LPAR1KDM4EMAPTTP53 | |
| SCHEMBL4028773 | 0.72 | MAPT (0.53) | LPAR1KDM4EMAPTTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |