Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.42 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032063 | 0.91 | LPAR1 (0.47) | KDM4EMAPTLPAR1LPAR3LPAR2 | |
| SCHEMBL4035059 | 0.83 | ALDH1A1 (0.51) | KDM4EMAPTLPAR1LPAR3LPAR2 | |
| SCHEMBL4028370 | 0.82 | LPAR1 (0.67) | KDM4EMAPTLPAR1TDP1LPAR3 | |
| SCHEMBL4038441 | 0.82 | HDAC1 (0.50) | KDM4EMAPTLPAR1LPAR3LPAR2 | |
| SCHEMBL4029454 | 0.81 | MAPT (0.46) | KDM4EMAPTLPAR1LPAR3LPAR2 | |
| SCHEMBL4037667 | 0.79 | LPAR1 (0.48) | KDM4EMAPTLPAR1LPAR3LPAR2 | |
| SCHEMBL4030241 | 0.76 | LPAR1 (0.42) | KDM4ELPAR1TDP1LPAR3LPAR2 | |
| SCHEMBL4029548 | 0.75 | ATM (0.57) | KDM4EMAPTLPAR1LPAR3LPAR2 | |
| SCHEMBL4034023 | 0.74 | LPAR1 (0.53) | KDM4EMAPTLPAR1LPAR3LPAR2 | |
| SCHEMBL4028843 | 0.74 | LPAR1 (0.70) | KDM4EMAPTLPAR1LPAR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |