Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4031792 | 0.91 | KDM4E (0.45) | LPAR1KDM4EMAPTLPAR3KMT2A | |
| SCHEMBL4037667 | 0.82 | LPAR1 (0.48) | LPAR1KDM4EMAPTLPAR3KMT2A | |
| SCHEMBL4028843 | 0.81 | LPAR1 (0.70) | LPAR1KDM4EMAPTL3MBTL1LPAR3 | |
| SCHEMBL4029548 | 0.80 | ATM (0.57) | LPAR1KDM4EMAPTLPAR3KMT2A | |
| SCHEMBL4029454 | 0.79 | MAPT (0.46) | LPAR1KDM4EMAPTLPAR3KMT2A | |
| SCHEMBL4035059 | 0.77 | ALDH1A1 (0.51) | LPAR1KDM4EMAPTLPAR3KMT2A | |
| SCHEMBL4035675 | 0.77 | MAPT (0.67) | LPAR1KDM4EMAPTLPAR3KMT2A | |
| SCHEMBL4034023 | 0.77 | LPAR1 (0.53) | LPAR1KDM4EMAPTLPAR3KMT2A | |
| SCHEMBL4038441 | 0.76 | HDAC1 (0.50) | LPAR1KDM4EMAPTLPAR3KMT2A | |
| SCHEMBL3706068 | 0.75 | MAPT (0.52) | LPAR1KDM4EMAPTLPAR3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |