Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 2/20 | 0.32 |
| ▸ | EDNRA | P25101 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3658384 | 0.90 | TSHR (0.36) | TSHRLMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL410941 | 0.88 | LMNA (0.38) | TSHRLMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL3661847 | 0.87 | TSHR (0.36) | TSHRLMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL3654462 | 0.87 | LMNA (0.34) | TSHRLMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL3656740 | 0.86 | TSHR (0.36) | TSHRLMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL3661060 | 0.85 | LMNA (0.35) | TSHRLMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL405714 | 0.83 | ANPEP (0.39) | LMNAHPGDSMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL3660480 | 0.83 | LMNA (0.39) | TSHRLMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL3657926 | 0.82 | LMNA (0.33) | TSHRLMNAHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL3658972 | 0.82 | LMNA (0.37) | TSHRLMNAHPGDSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102642-B2 | Herbicidally active cyclic diones and derivatives thereof, processes for their preparation, compositions, and methods of controlling weeds | SYNGENTA LIMITED (GB) | 2015-08-11 | — | — | US | disclosed |
| EP-2393796-B1 | NOVEL HERBICIDES | SYNGENTA LTD (GB) | 2015-02-25 | — | — | EP | disclosed |
| US-8895761-B2 | 4-phenylpyrane-3,5-diones, 4-phenylthiopyrane-3,5-diones and 2-phenylcyclohexane-1,3,5-triones as herbicides | SYNGENTA LIMITED (GB) | 2014-11-25 | — | — | US | disclosed |
| EP-2222657-B1 | PYRANDIONES, THIOPYRANDIONES AND CYCLOHEXANTRIONES HAVING HERBICIDAL PROPERTIES | SYNGENTA LTD (GB) | 2012-09-12 | — | — | EP | disclosed |
| US-20120021909-A1 | NOVEL HERBICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2012-01-26 | — | — | US | disclosed |
| EP-2393796-A1 | NOVEL HERBICIDES | Syngenta Limited (GB) | 2011-12-14 | — | — | EP | disclosed |
| US-20100279872-A1 | 4-PHENYLPYRANE-3,5-DIONES, 4-PHENYLTHIOPYRANE-3,5-DIONES AND 2-PHENYLCYCLOHEXANE-1,3,5-TRIONES AS HERBICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2010-11-04 | — | — | US | disclosed |
| EP-2222657-A1 | 4-PHENYLPYRANE-3,5-DIONES, 4-PHENYLTHIOPYRANE-3,5-DIONES AND 2-PHENYLCYCLOHEXANE-1,3,5-TRIONES AS HERBICIDES | Syngenta Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| WO-2010089211-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2010-08-12 | — | — | WO | disclosed |
| WO-2009074314-A1 | 4-PHENYLPYRANE-3,5-DIONES, 4-PHENYLTHIOPYRANE-3,5-DIONES AND 2-PHENYLCYCLOHEXANE-1,3,5-TRIONES AS HERBICIDES | SYNGENTA LIMITED (GB) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120021909-A1 | NOVEL HERBICIDES | DDT, CYP4X1, CYP1B1 | TSHR 1306/4885LMNA 4657/4885HPGD 2284/4885 |
| US-20100279872-A1 | 4-PHENYLPYRANE-3,5-DIONES, 4-PHENYLTHIOPYRANE-3,5-DIONES AND 2-PHENYLCYCLOHEXANE-1,3,5-TRIONES AS HERBICIDES | DDT, HPD, THOP1 | TSHR 325/4885LMNA 4797/4885HPGD 726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.