Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3034438 | 0.89 | L3MBTL1 (0.33) | LMNAMAPK1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL402954 | 0.88 | TSHR (0.40) | LMNAMAPK1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL3025240 | 0.83 | LMNA (0.42) | LMNAMAPK1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL868246 | 0.82 | LMNA (0.34) | LMNAMAPK1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL3034626 | 0.82 | TP53 (0.36) | LMNAMAPK1TSHRHPGDSMN1; SMN2 | |
| SCHEMBL417363 | 0.82 | HSD17B3 (0.38) | LMNAMAPK1HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL3024626 | 0.81 | LMNA (0.40) | LMNAMAPK1TSHRHPGDALDH1A1 | |
| SCHEMBL868610 | 0.80 | LMNA (0.39) | LMNAMAPK1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL3035400 | 0.80 | LMNA (0.39) | LMNAMAPK1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL867734 | 0.80 | LMNA (0.39) | LMNAMAPK1TSHRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387569-B1 | HERBCIDES | SYNGENTA LTD (GB) | 2016-06-15 | — | — | EP | disclosed |
| US-9006429-B2 | Herbicidal pyrandione, thiopyrandione, and cyclohexanetrione derivatives | SYNGENTA CROP PROTECTION, LLC (US) | 2015-04-14 | — | — | US | disclosed |
| US-8987476-B2 | Spiro epoxides as intermediates | SYNGENTA LIMITED (GB) | 2015-03-24 | — | — | US | disclosed |
| US-20140378305-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2014-12-25 | — | — | US | disclosed |
| US-8865623-B2 | Herbicidally active cyclic diones and derivatives thereof, processes for their preparation, compositions, and method of controlling weeds | SYNGENTA LIMITED (GB) | 2014-10-21 | — | — | US | disclosed |
| EP-2102181-B1 | 4-PHENYL-PYRANE-3,5-DIONES, 4-PHENYL-THIOPYRANE-3,5-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-06-18 | — | — | EP | disclosed |
| US-20140135508-A1 | SPIRO EPOXIDES AS INTERMEDIATES | SYNGENTA LIMITED (GB) | 2014-05-15 | — | — | US | disclosed |
| US-8680299-B2 | Spiro epoxides as intermediates | SYNGENTA LIMITED (GB) | 2014-03-25 | — | — | US | disclosed |
| US-8680012-B2 | 4-phenyl-pyrane-3,5-diones,4-phenyl-thiopyrane-3,6-diones and cyclohexanetriones as novel herbicides | SYNGENTA CROP PROTECTION LLC (US) | 2014-03-25 | — | — | US | disclosed |
| US-8623907-B2 | Herbicides | SYNGENTA PARTICIPATIONS, AG (CH) | 2014-01-07 | — | — | US | disclosed |
| EP-2313388-A1 | NOVEL HERBICIDES | Syngenta Limited (GB) | 2011-04-27 | — | — | EP | disclosed |
| EP-2313387-A1 | NOVEL HERBICIDES | Syngenta Participations AG (CH) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010136431-A9 | SPIRO EPOXIDES AS INTERMEDIATES | SYNGENTA LIMITED (GB) | 2011-03-10 | — | — | WO | disclosed |
| WO-2010136431-A1 | SPIRO EPOXIDES AS INTERMEDIATES | SYNGENTA LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| US-20100210466-A1 | 4-PHENYL-PYRANE-3,5-DIONES,4-PHENYL-THIOPYRANE-3,6-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-08-19 | — | — | US | disclosed |
| WO-2010081755-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |
| WO-2009150093-A1 | NOVEL HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009150094-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2009-12-17 | — | — | WO | disclosed |
| EP-2102181-A1 | 4-PHENYL-PYRANE-3,5-DIONES, 4-PHENYL-THIOPYRANE-3,5-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | Syngeta Participations AG (CH) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008071405-A1 | 4-PHENYL-PYRANE-3,5-DIONES, 4-PHENYL-THIOPYRANE-3,5-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-06-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210466-A1 | 4-PHENYL-PYRANE-3,5-DIONES,4-PHENYL-THIOPYRANE-3,6-DIONES AND CYCLOHEXANETRIONES AS NOVEL HERBICIDES | DDT, HPD, CYP4B1 | LMNA 4842/4885MAPK1 3174/4885TSHR 214/4885 |
| US-20140135508-A1 | SPIRO EPOXIDES AS INTERMEDIATES | CYP1A1, CYP2E1, GSTO1 | LMNA 2914/4885MAPK1 1509/4885TSHR 983/4885 |
| US-20140378305-A1 | NOVEL HERBICIDES | DDT, CYP4X1, CYP1B1 | LMNA 4151/4885MAPK1 2927/4885TSHR 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.