Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | PAM | P19021 | 2/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903419 | 1.00 | HTR2A (0.59) | HTR2APAMGRIK1GRIK2IDO1 | |
| SCHEMBL27669819 | 0.83 | HTR2A (0.66) | HTR2APAMGRIK1GRIK2IDO1 | |
| SCHEMBL21189126 | 0.83 | HTR2A (0.66) | HTR2APAMGRIK1GRIK2IDO1 | |
| SCHEMBL5475692 | 0.83 | HTR2A (0.66) | HTR2APAMGRIK1GRIK2IDO1 | |
| SCHEMBL5475689 | 0.83 | HTR2A (0.66) | HTR2APAMGRIK1GRIK2IDO1 | |
| SCHEMBL19604562 | 0.83 | HTR2A (0.66) | HTR2APAMGRIK1GRIK2IDO1 | |
| SCHEMBL15268410 | 0.83 | HTR2A (0.55) | HTR2APAMGRIK1GRIK2IDO1 | |
| SCHEMBL15441563 | 0.81 | HTR2A (0.53) | HTR2APAMGRIK1GRIK2IDO1 | |
| SCHEMBL6009944 | 0.81 | HTR2A (0.53) | HTR2APAMGRIK1GRIK2IDO1 | |
| SCHEMBL7514294 | 0.81 | HTR2A (0.53) | HTR2APAMGRIK1GRIK2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | UNIVERSITY OF NEBRASKA - LINCOLN | 2015-01-29 | — | — | US | disclosed |
| US-8859614-B2 | Analogues of (−)-picropodophyllin, synthesis and uses thereof | University of Nebraska—Lincoln (US) | 2014-10-14 | — | — | US | disclosed |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-10-29 | — | — | US | disclosed |
| WO-2009100349-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-08-13 | — | — | WO | disclosed |
| US-6051721-A | Ring E-modified analogues of(-)-podophyllotoxin and etoposide and a method for their synthesis | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2000-04-18 | — | — | US | disclosed |
| WO-1999018109-A1 | RING E-MODIFIED ANALOGUES OF (-)-PODOPHYLLOTOXIN AND ETOPOSIDE AND A METHOD FOR THEIR SYNTHESIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 1999-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | PPOX, HCCS, DHPS | HTR2A 3663/4885PAM 549/4885GRIK1 4255/4885 |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | PPOX, HCCS, DHPS | HTR2A 3751/4885PAM 672/4885GRIK1 4269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.