Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.41 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4036454 | 0.91 | LPAR1 (0.43) | MEN1KMT2AHTR5AHTR1ADRD2 | |
| SCHEMBL4030241 | 0.87 | LPAR1 (0.42) | HTR5ADRD2LPAR1LPAR2LPAR3 | |
| SCHEMBL4034939 | 0.86 | LPAR1 (0.45) | MEN1KMT2AHTR5ALPAR1LPAR2 | |
| SCHEMBL4032394 | 0.85 | LPAR1 (0.47) | MEN1KMT2ALPAR1LPAR2LPAR3 | |
| SCHEMBL4036696 | 0.85 | LPAR1 (0.44) | MEN1KMT2ALPAR1LPAR2LPAR3 | |
| SCHEMBL4028841 | 0.83 | LPAR1 (0.43) | MEN1KMT2ALPAR1LPAR2LPAR3 | |
| SCHEMBL4032920 | 0.81 | ATM (0.44) | MEN1KMT2ALPAR1LPAR2LPAR3 | |
| SCHEMBL4034499 | 0.81 | LPAR1 (0.48) | MEN1KMT2ALPAR1LPAR2LPAR3 | |
| SCHEMBL4032913 | 0.80 | LPAR1 (0.42) | MEN1KMT2ALPAR1LPAR2LPAR3 | |
| SCHEMBL4034108 | 0.79 | LPAR1 (0.44) | MEN1KMT2ALPAR1LPAR2LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |