Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | GLA | P06280 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.48 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL588713 | 0.87 | RAB9A (0.58) | KDM4EGLAMEN1KMT2AALPL | |
| SCHEMBL4025662 | 0.76 | SRD5A1 (0.61) | SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4032086 | 0.76 | SRD5A1 (0.41) | KDM4EMEN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL17108416 | 0.76 | MPO (0.59) | KDM4EGLAMAPTSMN1; SMN2RAB9A | |
| SCHEMBL11684649 | 0.76 | KDM4E (0.57) | KDM4EGLAMEN1KMT2AALPL | |
| SCHEMBL9376500 | 0.75 | MAPT (0.52) | KDM4EMEN1KMT2AHSD17B10MAPT | |
| SCHEMBL6325529 | 0.74 | MPO (0.59) | KDM4EGLAMEN1KMT2AALPL | |
| SCHEMBL3018274 | 0.73 | MIF (0.57) | KDM4EGLAMEN1KMT2AALPL | |
| SCHEMBL3018271 | 0.73 | MIF (0.57) | KDM4EGLAMEN1KMT2AALPL | |
| SCHEMBL9391395 | 0.73 | MIF (0.57) | KDM4EGLAMEN1KMT2AALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747201-B8 | 2H OR 3H-BENZO[E]INDAZOL-1-YLE CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2009-02-18 | — | — | EP | disclosed |
| EP-1747201-B1 | 2H OR 3H-BENZO[E]INDAZOL-1-YLE CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2008-10-15 | — | — | EP | disclosed |
| EP-1747201-A1 | 2H OR 3H-BENZO[E]INDAZOL-1-YLE CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005121099-A1 | 2H OR 3H-BENZO[E]INDAZOL-1-YLE CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2005-12-22 | — | — | WO | disclosed |