Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | MIF | P14174 | 4/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4030552 | 0.87 | KDM4E (0.57) | RAB9AMAPTKDM4EGLAATM | |
| SCHEMBL588072 | 0.82 | MAPK14 (0.43) | RAB9AMAPTKDM4EGLAATM | |
| SCHEMBL587938 | 0.82 | SRD5A1 (0.48) | RAB9AMAPTKDM4EGLAATM | |
| SCHEMBL14812784 | 0.77 | MAPT (0.55) | RAB9AMAPTKDM4EGLAATM | |
| SCHEMBL9376500 | 0.77 | MAPT (0.52) | RAB9AMAPTKDM4EGAANPC1 | |
| SCHEMBL17108416 | 0.75 | MPO (0.59) | RAB9AMAPTKDM4EGLAATM | |
| SCHEMBL6648373 | 0.73 | L3MBTL1 (0.42) | MAPTKDM4ETDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL14355553 | 0.73 | MPO (0.56) | RAB9AMAPTKDM4EGLAATM | |
| SCHEMBL30940179 | 0.73 | MPO (0.56) | RAB9AMAPTKDM4EGLAATM | |
| SCHEMBL20644283 | 0.73 | MAPK14 (0.59) | RAB9AMAPTKDM4EGLAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258168-B2 | 2H or 3H-benzo[E]indazol-1-YL carbamate derivatives, the preparation and therapeutic use thereof | SANOFI (FR) | 2012-09-04 | — | — | US | disclosed |
| US-20120108584-A1 | 2H OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2012-05-03 | — | — | US | disclosed |
| US-8114899-B2 | 2H- or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2012-02-14 | — | — | US | disclosed |
| US-20090143380-A1 | 2H- OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-06-04 | — | — | US | disclosed |
| US-7501449-B2 | 2H -or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-03-10 | — | — | US | disclosed |
| US-20070105932-A1 | 2H-or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105932-A1 | 2H-or 3H-benzo[e]indazol-1-yl carbamate derivatives, the preparation and therapeutic use thereof | GLS2, GLS, CYP11B2 | RAB9A 1148/4885MAPT 2383/4885KDM4E 445/4885 |
| US-20090143380-A1 | 2H- OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | GLS2, GLS, SDHA | RAB9A 1178/4885MAPT 2287/4885KDM4E 432/4885 |
| US-20120108584-A1 | 2H OR 3H-BENZO[E]INDAZOL-1-YL CARBAMATE DERIVATIVES, THE PREPARATION AND THERAPEUTIC USE THEREOF | GLS2, GLS, SDHA | RAB9A 988/4885MAPT 2237/4885KDM4E 456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.