Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.32 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821371 | 0.89 | LMNA (0.41) | LMNATSHRADORA3MC4RADRA1A | |
| SCHEMBL8698385 | 0.85 | LMNA (0.39) | LMNATSHRALOX15KDM4EACMSD | |
| SCHEMBL87944 | 0.85 | ALOX15 (0.41) | LMNATSHRALOX15KDM4EACMSD | |
| SCHEMBL27627380 | 0.82 | LMNA (0.36) | LMNATSHRADORA3MC4RADRA1A | |
| SCHEMBL29954040 | 0.79 | KDM4E (0.37) | LMNATSHRALOX15KDM4EACMSD | |
| Pyrrole SCHEMBL5232814 | 0.79 | LMNA (0.34) | LMNAALDH1A1PIM1 | |
| SCHEMBL311179 | 0.78 | KDM4E (0.35) | LMNATSHRALOX15KDM4EACMSD | |
| SCHEMBL5806554 | 0.77 | MAPK1 (0.40) | TSHRKDM4ESIRT6ALDH1A1 | |
| SCHEMBL3706189 | 0.75 | KDM4E (0.42) | LMNATSHRKDM4ETDP1ALDH1A1 | |
| SCHEMBL161337 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534686-B1 | NF-KB INHIBITORS AND USES THEREOF | UNIV MICHIGAN STATE (US) | 2009-05-20 | — | — | EP | disclosed |