Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821371 | 0.86 | LMNA (0.41) | LMNATSHRADORA3MC4RADRA1A | |
| SCHEMBL87944 | 0.86 | ALOX15 (0.41) | LMNATSHRALDH1A1ALOX15TDP1 | |
| SCHEMBL4030743 | 0.85 | LMNA (0.38) | LMNATSHRADORA3MC4RADRA1A | |
| SCHEMBL28658514 | 0.84 | ALOX15 (0.34) | LMNATSHRALOX15TDP1KDM4E | |
| SCHEMBL27363729 | 0.81 | LMNA (0.32) | LMNATSHRALDH1A1ALOX15TDP1 | |
| SCHEMBL9387500 | 0.78 | TDP1 (0.33) | LMNATSHRALDH1A1ALOX15TDP1 | |
| SCHEMBL11168226 | 0.77 | SIRT6 (0.42) | LMNATSHRADORA3MC4RADRA1A | |
| Pyrrole SCHEMBL5232814 | 0.76 | LMNA (0.34) | LMNAALDH1A1PIM1 | |
| SCHEMBL780237 | 0.76 | — | — | |
| SCHEMBL27627380 | 0.75 | LMNA (0.36) | LMNATSHRADORA3MC4RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998046573-A1 | 2-SUBSTITUTED CARBAMOYLIMIDAZOLECARBOXYLIC ACID DERIVATIVES AND VASCULAR-WALL THICKENING INHIBITOR | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1998-10-22 | — | — | WO | disclosed |