Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28038835 | 0.86 | TP53 (0.54) | TRPM8TP53MEN1KMT2ACYP3A4 | |
| SCHEMBL30443001 | 0.85 | CYP3A4 (0.54) | TRPM8TP53MEN1KMT2ACYP3A4 | |
| SCHEMBL12117477 | 0.85 | CYP3A4 (0.54) | TRPM8TP53MEN1KMT2ACYP3A4 | |
| SCHEMBL28038889 | 0.83 | TP53 (0.62) | TRPM8TP53MEN1KMT2ACYP3A4 | |
| SCHEMBL28039146 | 0.83 | TP53 (0.62) | TRPM8TP53MEN1KMT2ACYP3A4 | |
| SCHEMBL28039137 | 0.83 | TP53 (0.62) | TRPM8TP53MEN1KMT2ACYP3A4 | |
| SCHEMBL28823423 | 0.83 | TP53 (0.62) | TRPM8TP53MEN1KMT2ACYP3A4 | |
| SCHEMBL1644746 | 0.82 | TRPM8 (0.44) | TRPM8TP53MEN1KMT2ACYP3A4 | |
| SCHEMBL8709978 | 0.82 | CYP3A4 (0.41) | TRPM8TP53MEN1KMT2ACYP3A4 | |
| SCHEMBL1624311 | 0.80 | SMN1; SMN2 (0.51) | TP53MEN1KMT2ACYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660091-B1 | PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES INC (US) | 2009-04-15 | — | — | EP | disclosed |
| US-7329669-B2 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-02-12 | — | — | US | disclosed |
| US-20070015778-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2007-01-18 | — | — | US | disclosed |
| US-7071200-B2 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1660091-A1 | PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2006-05-31 | — | — | EP | disclosed |
| US-20050043338-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-02-24 | — | — | US | disclosed |
| WO-2005007164-A1 | PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043338-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, GHRHR, LHCGR | TRPM8 1451/4885TP53 3410/4885MEN1 578/4885 |
| US-20070015778-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, GHRHR, LHCGR | TRPM8 1451/4885TP53 3410/4885MEN1 578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.