Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | AGXT | P21549 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PLEC | Q15149 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | CA3 | P07451 | 1/20 | 0.30 |
| ▸ | CA6 | P23280 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31021710 | 0.79 | DPP4 (0.37) | IDO1DPP4PKMRIPK1AGXT | |
| SCHEMBL156831 | 0.79 | DPP4 (0.37) | IDO1DPP4PKMRIPK1AGXT | |
| SCHEMBL29374861 | 0.79 | DPP4 (0.37) | IDO1DPP4PKMRIPK1AGXT | |
| SCHEMBL12151763 | 0.77 | DPP4 (0.36) | IDO1DPP4PKMRIPK1AGXT | |
| SCHEMBL3075261 | 0.77 | DPP4 (0.36) | IDO1DPP4PKMRIPK1AGXT | |
| SCHEMBL5430076 | 0.77 | PKM (0.38) | IDO1DPP4PKMRIPK1AGXT | |
| SCHEMBL322033 | 0.77 | GABRA1 (0.39) | DPP4PKMRIPK1KMT2AMEN1 | |
| SCHEMBL147653 | 0.77 | DPP4 (0.36) | IDO1DPP4PKMRIPK1AGXT | |
| SCHEMBL558725 | 0.77 | MPO (0.44) | IDO1DPP4PKMRIPK1AGXT | |
| SCHEMBL30227514 | 0.77 | PKM (0.38) | IDO1DPP4PKMRIPK1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345899-B1 | N-substituted amides as NK1 receptor antagonists | ASTRAZENECA AB (SE) | 2009-01-14 | — | — | EP | disclosed |
| US-7064136-B2 | Compounds | ASTRAZENECA AB (SE) | 2006-06-20 | — | — | US | disclosed |
| US-20040058916-A1 | Compounds | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | US | disclosed |
| EP-1345899-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051807-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058916-A1 | Compounds | CYP11B2, CYP11B1, PCSK9 | IDO1 3047/4885DPP4 456/4885PKM 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.