Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4027976 | 0.85 | MAPT (0.49) | ALDH1A1PKMTRPA1TP53LMNA | |
| SCHEMBL4034308 | 0.84 | KDM4E (0.49) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL4304 | 0.83 | RAB9A (0.40) | ALDH1A1TP53MAPTRXFP1SMN1; SMN2 | |
| SCHEMBL4033611 | 0.81 | LPAR1 (0.40) | ALDH1A1TP53MAPTSMN1; SMN2KDM4E | |
| SCHEMBL4029624 | 0.77 | LPAR1 (0.59) | — | |
| SCHEMBL13960108 | 0.75 | CYP2A6 (0.41) | TP53LMNAMAPTDHODHKDM4E | |
| SCHEMBL3704614 | 0.71 | TRPA1 (0.56) | ALDH1A1PKMTRPA1TP53LMNA | |
| SCHEMBL15464353 | 0.71 | PTPN1 (0.45) | ALDH1A1PKMTRPA1TP53LMNA | |
| SCHEMBL4036888 | 0.71 | LPAR1 (0.47) | ALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL15013106 | 0.71 | LPAR1 (0.50) | ALDH1A1TRPA1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |