Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.48 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.40 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304 | 0.87 | RAB9A (0.40) | KDM4EMAPTLPAR1LPAR3NPC1 | |
| SCHEMBL4036888 | 0.86 | LPAR1 (0.47) | KDM4EMAPTLPAR1LPAR3NPC1 | |
| SCHEMBL4033611 | 0.85 | LPAR1 (0.40) | KDM4EMAPTLPAR1LPAR3NPC1 | |
| SCHEMBL4031154 | 0.84 | ALDH1A1 (0.41) | KDM4EMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4035675 | 0.83 | MAPT (0.67) | KDM4EMAPTLPAR1LPAR3PTGS1 | |
| SCHEMBL8479643 | 0.78 | TSHR (0.46) | KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL11377985 | 0.78 | PTGS1 (0.50) | KDM4ENPC1RAB9APTGS1PTPN1 | |
| SCHEMBL4032733 | 0.77 | LPAR1 (0.65) | KDM4EMAPTLPAR1LPAR3 | |
| SCHEMBL11517550 | 0.76 | PTGS1 (0.48) | KDM4EMAPTNPC1RAB9APTGS1 | |
| SCHEMBL343798 | 0.75 | LPAR1 (0.65) | MAPTLPAR1LPAR3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | disclosed |