Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706068 | 0.86 | MAPT (0.52) | LPAR1MAPTKDM4ELPAR3LPAR2 | |
| SCHEMBL4034308 | 0.85 | KDM4E (0.49) | LPAR1MAPTKDM4ELPAR3NPC1 | |
| SCHEMBL4304 | 0.84 | RAB9A (0.40) | LPAR1MAPTKDM4ELPAR3NPC1 | |
| SCHEMBL4031154 | 0.81 | ALDH1A1 (0.41) | MAPTKDM4ESMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL4029487 | 0.79 | LPAR1 (0.48) | LPAR1MAPTKDM4ELPAR3LPAR2 | |
| SCHEMBL4028539 | 0.77 | LPAR1 (0.53) | LPAR1LPAR3LPAR2 | |
| SCHEMBL4037667 | 0.73 | LPAR1 (0.48) | LPAR1MAPTKDM4ELPAR3LPAR2 | |
| SCHEMBL4032753 | 0.73 | TP53 (0.53) | LPAR1MAPTKDM4ELPAR3LPAR2 | |
| SCHEMBL3702392 | 0.72 | BACE1 (0.40) | LPAR1MAPTKDM4ELPAR3LPAR2 | |
| SCHEMBL4036888 | 0.72 | LPAR1 (0.47) | LPAR1MAPTKDM4ELPAR3LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |