Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029460 | 0.80 | NPSR1 (0.61) | PTGS1ALDH1A1MAPTGAAKMT2A | |
| SCHEMBL30395326 | 0.79 | GPBAR1 (0.60) | EPAS1GPBAR1PTGS1ALDH1A1LMNA | |
| SCHEMBL3826089 | 0.79 | GPBAR1 (0.60) | EPAS1GPBAR1PTGS1ALDH1A1LMNA | |
| SCHEMBL27936741 | 0.78 | GPBAR1 (0.62) | EPAS1GPBAR1PTGS1ALDH1A1LMNA | |
| SCHEMBL4031817 | 0.77 | MAPT (0.47) | EPAS1ALDH1A1MAPTGAAKMT2A | |
| SCHEMBL2470614 | 0.77 | GPBAR1 (0.60) | EPAS1GPBAR1PTGS1ALDH1A1LMNA | |
| SCHEMBL4028725 | 0.77 | MAPT (0.49) | GPBAR1ALDH1A1LMNAMAPTGAA | |
| SCHEMBL4032662 | 0.77 | LPAR1 (0.57) | GPBAR1SCN9ASCN5AALDH1A1LMNA | |
| SCHEMBL28807438 | 0.76 | GABRA5 (0.51) | EPAS1GPBAR1PTGS1ALDH1A1LMNA | |
| SCHEMBL11408570 | 0.76 | EPAS1 (0.61) | EPAS1GPBAR1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |